Wuzhong has a long history dating back to the Han Dynasty, when the Yellow River irrigation channels were first constructed, bringing agriculture to the arid plains. The area flourished as a trading post on the ancient Silk Road, with caravans stopping to rest and resupply in this river-adjacent oasis.
During the Ming and Qing dynasties, Wuzhong developed into a major agricultural center, known particularly for its grains and livestock. The Hui Muslim community established deep roots here, and Islamic culture became an integral part of the city's identity.
In the modern era, Wuzhong has balanced industrial development with the preservation of its agricultural heritage. Goji berry cultivation has been modernized and expanded, and food processing has become a key economic sector. The city has invested in ecological restoration along the Yellow River, creating the wetlands park that now serves as both a conservation area and a recreational space.