Qianxinan has been inhabited since ancient times, with archaeological evidence of human activity dating back 10,000 years. The Buyi people, the region's largest ethnic group, are descendants of the ancient Baiyue tribes that inhabited southern China.
During the Tang and Song dynasties, the region was under the control of local chieftains who governed semi-autonomously. The Ming Dynasty (1368-1644) began incorporating the area more directly into the Chinese administrative system, though local chieftain systems continued.
The Qing Dynasty further consolidated control, encouraging Han Chinese migration to the region. In 1956, the Qianxinan Buyi and Miao Autonomous Prefecture was formally established to recognize the region's ethnic diversity and grant self-governance.
Historically isolated by its mountainous terrain, Qianxinan remained poor and underdeveloped until recent decades. Major infrastructure improvements — highways, the Nan-Kun Railway, and the nearby Xingyi Wanfenglin Airport — have transformed accessibility and economic prospects.