Bozhou's history extends back over 3,700 years to the Shang Dynasty, when it served as an important settlement. The city reached its peak during the Eastern Han and Three Kingdoms periods (2nd-3rd century CE) as the power base of Cao Cao, who unified northern China and established the Kingdom of Wei.
Cao Cao was not only a military and political genius but also a celebrated poet whose verses are still studied today. His son Cao Pi founded the Wei Dynasty (220-265 CE), formally ending the Han Dynasty. The underground tunnels built by Cao Cao demonstrate his strategic brilliance.
During the Ming and Qing dynasties, Bozhou flourished as a commercial centre, and the Huaxilou opera stage was built by wealthy merchants from Shanxi and Shaanxi. The city's position on the Grand Canal trade network brought prosperity and cultural exchange.
In modern times, Bozhou has grown into a major centre for traditional Chinese medicine, hosting one of China's largest herbal medicine markets. The city balances its ancient heritage with modern industry, particularly in medicine production and liquor brewing.